WebABSTRACT: Thiaplakortone A (3a), an antimalarial natural product, was prepared by an operationally simple and scalable synthesis. In our efforts to deliver a lead compound … WebThiaplakortone A (3a), an antimalarial natural product, was prepared by an operationally simple and scalable synthesis. In our efforts to deliver a lead compound with improved potency, metabolic stability, and selectivity, the synthesis was diverted to access a series of analogues. Compounds 3a–d showed nanomolar activity against the chloroquine …

Synthesis and Antiplasmodial Evaluation of Analogues Based on …

Webthrough a diverted total synthesis of thiaplakortone A (3a). Herein we report the first total synthesis of 3a, along with several thiaplakortone-based analogues (3b−d, 17). The in vitro antimalarial activity and mammalian cell toxicity studies for all compounds is also reported as well as metabolic profiling Web15 Sep 2015 · Synthesis of compounds 11–16 in the thiaplakortone tricyclic series. (a) 2-aminoethanesulfinic acid, H2O, MeCN; (b) NaHCO3(aq), MeOH, reflux 2.5 h; (c) KOH(aq), … old rick springfield

Biological profiles of amide analogues 8-32 Download Table

Web(+)-Glioclandin B is an epidithiodiketopiperazine alkaloid belonging to mycotoxin class of compounds isolated from fungal strain of Gliocladium roseum. First-generation and … WebThiaplakortone B attenuates RANKL‐induced NF‐κB and MAPK signaling and dampens OVX‐induced bone loss in mice Biomedicine and Pharmacotherapy 2024-10 Journal article Author DOI: 10.1016/j.biopha.2024.113622 SOURCE-WORK-ID: 25516eba-03d2-4aaf-81d6-4cc7909cb388 EID: 2-s2.0-85137280061 PMID: 36081291 WebLoop is the open research network that increases the discoverability and impact of researchers and their work. Loop enables you to stay up-to-date with the latest discoveries and news, connect with researchers and form new collaborations. my office files