site stats

Sphk1 cancer

WebNov 8, 2024 · Sphingosine kinases (SPHKs) are conserved lipid enzymes that catalyze the formation of sphingosine-1-phosphate (S1P) through ATP-dependent phosphorylation of sphingosine. Two distinct SPHK isoforms, namely SPHK1 and SPHK2, have been identified to date, and the former has been implicated for its oncogenic roles in cancer development … WebApr 1, 2011 · Abstract. Purpose: The present study was to examine the effect of sphingosine kinase-1 (SPHK1) on chemotherapeutics-induced apoptosis in non-small cell lung cancer (NSCLC) cells, which is relatively insensitive to chemotherapy, and its clinical significance in NSCLC progression.

IJMS Free Full-Text The Effect of Silencing the Genes …

WebAug 15, 2008 · SphK1 的表达在癌症（包括白血病）中上调，并与癌症进展相关。 筛选出的鞘氨醇类似物鉴定为 (2R,3S,4E)-N-methyl-5- (4'-pentylphenyl)-2-aminopent-4-ene-1,3-diol，命名为 SK1-I (BML-258) ，作为 SphK1 的有效、水溶性、同工酶特异性抑制剂。 与 pan-SphK 抑制剂相比，SK1-I 不抑制 SphK2、PKC 或许多其他蛋白激酶。 SK1-I 降低人白血病 … WebMar 3, 2024 · SPHK1 expression was closely correlated with RCC progression-related clinicopathological parameters. Therefore, elevated SPHK1 could effectively diagnose RCC and distinguish RCC with an advanced clinical stage and a high pathological grade. ... Renal cell carcinoma (RCC) is the sixth most frequently diagnosed cancer in male patients and … ca\\u0027 zg https://wilhelmpersonnel.com

Roles of sphingosine-1-phosphate signaling in cancer

WebMar 31, 2024 · SPHK1 was associated with the stemness of RCC cells via the activation of the Wnt, Hedgehog, or Notch signaling pathways in targeted drug-treated or untreated RCC. Survival analysis of a large cohort of RCC samples indicated overexpression of SPHK1 to be inversely correlated with the overall and disease-free survival of patients with RCC. WebNot only has elevated SPHK1 in cancer tissues been implicated in disease progression, but systemic SPHK1 has been implicated in promoting metastasis through a feedback mechanism whereby systemic S1P, signalling through tumour cell S1P 2 receptors, suppresses the expression of the protein breast carcinoma metastasis suppressor 1, … WebSPHK1 is involved in tumor development and progression of cervical cancer The silencing of SphK1 potentiated the apoptotic effects of the green tea polyphenol epigallocatechin-3-O-gallate. increased SK and SPL mRNA expression along with reduced sphingosine 1-phosphate levels were more commonly observed in hepatocellular carcinoma tissues. ca\u0027 zenobio venezia

Cancers Free Full-Text Regulatory Role of Sphingosine-1 …

Category:Different Roles of Sphingosine Kinase 1 and 2 in Pancreatic Cancer …

Tags:Sphk1 cancer

Sphk1 cancer

Overexpression of SPHK1 associated with targeted therapy …

WebJul 12, 2024 · Sphingosine kinase 1 (SphK1) and sphingosine kinase (SphK2) are both important therapeutic targets of non-small cell lung cancer (NSCLC). SKI-349 is a novel, … WebNov 8, 2024 · In the context of cancer, SPHK1 is the main isoform that is functionally associated with the hallmarks of cancer, which has been universally recognized as a key …

Sphk1 cancer

Did you know?

WebMar 3, 2024 · Sphingosine kinase 1 (SPHK1) is a key enzyme that catalyzes the phosphorylation of sphingosine. Recent studies reported SPHK1 to be associated with renal cell carcinoma (RCC) progression by inducing targeted therapy resistance. WebAbstract. The role of phospholipid signaling in ovarian cancer is poorly understood. Sphingosine-1-phosphate (S1P) is a bioactive metabolite of sphingosine that has been associated with tumor progression through enhanced cell proliferation and motility.

WebApr 29, 2016 · SphK1 promoted cancer growth via multiple mechanisms, including S1P signaling to cancer cells. Sequestering S1P with a specific S1P monoclonal antibody … WebFeb 27, 2014 · This upregulation of SphK1 promotes colon cancer cell survival 8, 9 and adenoma progression by enhancing cell proliferation. 17 The contribution of SphK1 …

WebJun 6, 2024 · SphK1 expression regulates the early stage of colon carcinogenesis and tumor growth, thus inhibition of SphK1 may be an effective strategy for colon cancer chemoprevention. Accumulating evidence suggests that sphingosine kinase 1 (SphK1)/sphingosine 1-phosphate pathway plays a pivotal role in colon carcinogenesis.

WebAbstract Introduction: Overexpression of sphingosine kinase 1 (SphK1) is casually associated with many types of cancer and inhibitors of SphK1 sensitize tumors to chemotherapy. SphK1 is expressed as two major isoforms, SphK1a and SphK1b. To date, no information has been reported on the SphK1 isoform expression profile and its clinical …

WebMar 20, 2024 · Therapeutic target of sphingosine kinases (SPHK) 1 and 2 has opened new opportunities in the treatment combinations of cancer patients. We previously reported that the dual SPHK1/2 inhibitor, SKI-II enhanced the in vitro cell death triggered by fludarabine, bendamustine or ibrutinib and reduced the activation and proliferation of chronic ... ca\u0027 zenobio trevisoWebApr 1, 2024 · S1P generated by activation of sphingosine kinase 1 (SphK1) is exported out of cells and signals through specific S1P receptors to regulate numerous cellular processes important for breast cancer, including cell growth, survival, invasion, immune cell trafficking, vascular integrity, angiogenesis, and cytokine and chemokine production ( 22–25 ). ca\\u0027 ziWebFeb 27, 2014 · The effects of SphK1 inhibition on colon cancer cell viability and the phosphoinositide 3-kinase (PI3K)/Akt cell survival pathway were investigated using a SphK1-selective inhibitor—compound 5c (5c). The cytotoxicity of a novel combination using SphK1 inhibition with the chemotherapeutic drug, 5-fluorouracil (5-FU), was also determined. … ca\\u0027 zjWebSphingosine kinase 1 (SPHK1) is a lipid kinase that phosphorylates sphingosine to generate S1P. S1P has been proven to be positively correlated with chemotherapy resistance in breast cancer, colorectal carcinoma and non‑small cell lung cancer. However, whether SPHK1 is involved in the development of cisplatin resistance remains to be elucidated. ca\u0027 ziWebApr 13, 2024 · SPHK1 is mainly localized in cytoplasm and plasma membrane and releases S1P both intra- and extracellularly, whereas SPHK2 localizes in the nucleus, mitochondria, and endoplasmic reticulum and produces intracellular S1P [ 12 ]. ca\\u0027 zenobio trevisoWebThe SPHK1-induced autophagy in HPMCs increased the invasive capability of gastric cancer cells, whereas SPHK1 knockdown inhibited autophagy. This was associated with a poor prognosis and recurrence in these patients. SPHK1 is also involved in the production of ceramide, a prominent lipid metabolite that will be discussed in the following section. ca\\u0027 zlWebIn particular, one of the kinases that produces S1P, sphingosine kinase 1 (SphK1), has come under increasing scrutiny as it is commonly upregulated in breast cancer cells and has … ca\\u0027 zk