Web11. jan 2024 · To comprehensively reveal the biological roles of liver enzymes, herein, we performed a phenome-wide MR study using data from the UK Biobank cohort study. Materials and Methods. Study Participants. This research has been conducted using the UK Biobank Resource under application numbers 58484 and 63726. Web13. sep 2024 · We then implemented a Mendelian Randomization–Phenome Wide Association Study (MR-PheWAS) analysis on data from 339 256 individuals of White British origin from UK Biobank. We first ran a PheWAS analysis to test the associations between a 25(OH)D polygenic risk score and 920 disease outcomes, and then nine phenotypes (i.e. …
Association between Human Blood Metabolome and the Risk of …
Web15. mar 2024 · MR analysis from phenome-wide traits to atrial fibrillation MR analyses suggested that out of 5048 exposures (3046 non-protein measures and 2002 proteins), 55 traits were putatively causal (Bonferroni P <1 x 10 -5 from IVW MR) for the development of atrial fibrillation ( Figures 2 and 3 ). Web9. apr 2024 · Finally, we conducted phenome-wide scans and pathway enrichment of relevant variants to reduce risks of horizontal pleiotropy and other biases due to MR violations as well as to understand... date postponed
Actionable druggable genome-wide Mendelian randomization ... - Nature
Web26. feb 2024 · Phenome-wide Mendelian randomization (MR) analysis has been proposed as a hypothesis-searching approach to comprehensively examine causality between … Webpred 2 dňami · A phenome-wide Mendelian randomization (MR) study of anti-VZV immunoglobulin G (IgG) levels with 1370 traits was conducted to explore the potential causal role of VZV-specific immune response on multiple traits using the UK Biobank cohort. For the robustness of the results, we performed MR analyses using five different … Web26. mar 2024 · In summary, we provided a phenome-wide view of the effects of childhood BMI on adult traits. Multivariable MR analysis suggested that the associations between … date pont ascension