Mitoferrin1/2
Web1 jan. 2024 · Interference of key regulators of mitochondrial lipid metabolism (e.g., ASCF2 and CS), iron homeostasis (e.g., ferritin, mitoferrin1/2 and NEET proteins), glutamine …
Mitoferrin1/2
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WebResults: Lysosomal iron release and mitochondrial iron uptake through mitoferrin-2 (Mfrn2) acted synergistically to induce PDT-mediated and iron-dependent mitochondrial dysfunction and cell killing. Conclusion: Mfrn2 plays a critical … WebSLC25A37 [mitochondrial inner membrane] Stable Identifier. R-HSA-1362389
Web1 feb. 2011 · Mitoferrin1 is 1 of 2 homologous mitochondrial iron transporters and is required for mitochondrial iron delivery in developing erythroid cells. We show that total … Mfrn1 is paralogous to Mitoferrin-2 (Mfrn2), a 39 kDa protein encoded by the SLC25A28 gene in humans. Mfrn1 is highly expressed in differentiating erythroid cells and in other tissues at low levels, while Mfrn2 is expressed ubiquitously in non-erythroid tissues. Meer weergeven Mitoferrin-1 (Mfrn1) is a 38 kDa protein that is encoded by the SLC25A37 gene in humans. It is a member of the Mitochondrial carrier (MC) Superfamily, however, its metal cargo makes it distinct from other … Meer weergeven The molecular details of iron trafficking for heme and Iron-sulfur cluster synthesis are still unclear, however, Mitoferrin-1 has been shown to form oligomeric complexes with the Meer weergeven The importance of Mitoferrins in heme and Fe-S cluster biosynthesis was first discovered in the anemic zebrafish mutant frascati. Studies in mice revealed that total deletion of … Meer weergeven Mitoferrin-1 has been implicated in diseases associated with defective iron homeostasis, resulting in iron or porphyrin imbalances. … Meer weergeven • Solute carrier family Meer weergeven • Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. • Suzuki Y, … Meer weergeven
Web7 aug. 2024 · Mitochondrial iron import is essential for iron-sulfur cluster formation and heme biosynthesis. Two nuclear-encoded vertebrate mitochondrial high-affinity iron importers, … Web7 aug. 2024 · Placing animals on a low-iron diet exaggerated the reduction in mitochondrial iron observed in liver-specific Mfrn1/2-knockout animals. ... The plasmids and viral vectors for the TET-regulated human mitoferrin1-GFP lentiviral system were generated and provided by the CCEH Vector Core at the Fred Hutchinson, Seattle, WA, ...
Web14 mrt. 2014 · Iron is imported into mitochondria via two transporters: mitoferrin-1 (MFRN1, SLC25A37) and mitoferrin-2 (MFRN2, SLC25A28). MFRN2 is expressed ubiquitously, whereas MFRN1 is specifically induced in differentiating erythroid cells ( 5, 6, 7 ).
WebAs inferred from biochemical studies in yeast and phenotypic studies in mouse, Mitoferrin-1 (SLC25A37) and Mitoferrin-2 (SLC25A28) transport ferrous iron across the inner mitochondrial membrane. Mitoferrin-1 is essential for maintaining mitochondrial iron uptake in developing erythroid cells; mitoferrin-2 is ubiquitously expressed. jp morgan assessment of valueWebTwo nuclear-encoded vertebrate mitochondrial high-affinity iron importers, mitoferrin1 (Mfrn1) and Mfrn2, have been identified in mammals. In mice, the gene encoding Mfrn1, solute carrier family 25 member 37 ( Slc25a37 ), is highly expressed in sites of erythropoiesis, and whole-body Slc25a37 deletion leads to lethality. jp morgan associate salary singaporeWeb16 nov. 2008 · Abstract. We previously identified the mitochondrial solute carrier, Mitoferrin1 (Slc25a37, Mfrn1) as the principal mitochondrial iron importer essential for … jpmorgan asian total return bond fundWeb22 sep. 2009 · By using positional cloning, we identified mitoferrin1 (mfrn1, slc25a37), a member of the mitochondrial solute carrier family, as the gene disrupted in frs mutants . … how to make a sand poolWeb13 jun. 2024 · Cytosolic iron enters mitochondria by mitoferrin1/2 and is used for the synthesis of heme, formation of Fe-S clusters, and storage in mitochondrial ferritin (MtPt). The enhanced accumulation of labile iron in mitochondria induces … how to make a sand snowmanWeb20 nov. 2024 · Mitoferrin-2 1. Introduction Both mitochondrial impairment and impaired iron homeostasis have been associated with neurodegenerative diseases, such as Morbus Parkinson (PD), Alzheimer´s disease (AD) and amyotrophic lateral sclerosis (ALS) [ … jp morgan asia growth fundWeb7 rijen · Product Information. 26469-1-AP targets Mitoferrin 1 in WB, IHC, ELISA applications and shows reactivity with human, mouse samples. PBS with 0.02% sodium … how to make a sand tornado