WebAug 1, 2024 · The Coxsackie and adenovirus receptor CXADR or CAR, also known as CAR-like membrane protein (CLMP) ... Similarly, a pro-inflammatory environment induced by … WebApr 16, 2024 · The mRNA for CXADR is alternatively spliced resulting in five protein isoforms (Fig. 1) []. Three out of five of these isoforms are missing the transmembrane domain and can be secreted out of the cell (CAR 2/7, 3/7, 4/7). ... Moreover, pro-inflammatory cytokines, such as IL-8, increase the apical localization of both CAR Ex8 …
The coxsackie-adenovirus receptor induces an inflammatory ...
WebThe interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. WebJan 29, 2024 · Title: Induction of the Coxsackievirus and Adenovirus Receptor in Macrophages During the Formation of Atherosclerotic Plaques. the Cxadr-Adam10 complex might moderate TJ integrity/stability and play pivotal roles during early embryonic development. Title: The Cxadr-Adam10 complex plays pivotal roles in tight junction … bakbouka
CXADR‐like membrane protein protects against heart injury by …
WebA novel pyroptotic insight into the ischaemic heart is provided, which might hold substantial potential for the treatment of MI. Myocardial infarction (MI) results in cardiomyocyte death and ultimately leads to heart failure. Pyroptosis is a type of the inflammatory programmed cell death that has been found in various diseased tissues. However, the role of … WebJan 11, 2024 · To create a new anti-tumor antibody, we conducted signal sequence trap by retrovirus-meditated expression method and identified coxsackie virus and adenovirus receptor (CXADR) as an appropriate ... WebCXADR induces stress-activated mitogen-activated protein kinase (MAPK) pathways in the heart, which results in increased production of IFNγ, IL-12, IL-1β, TNFα, and IL-6. These inflammatory cytokines are linked to M1 inflammatory response and this response is overactivated in Down′s syndrome (DS) due to increased expression of CXADR. bakboter blueband