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Clptml1 cancer scholar

WebJul 7, 2010 · Abstract. Background: A recent study reported genetic variants in the TERT-CLPTM1L locus that were associated with mean telomere length, and with risk of multiple cancers.Methods: We evaluated the association between single nucleotide polymorphism (SNP) rs401681 (C > T) and mean telomere length, using quantitative real-time PCR, in … WebJul 9, 2014 · Introduction. Esophageal cancer was the fifth most commonly diagnosed cancer and the fourth leading cause of cancer-related death in China in 2009 .Esophageal cancer is very aggressive and is associated with a poor prognosis .Esophageal squamous cell carcinoma (ESCC) accounts for more than 90 percent of esophageal cancers …

A TERT-CLPTM1 locus polymorphism (rs401681) is

WebMay 22, 2009 · Introduction. Lung cancer is the most common cancer worldwide, both in terms of incidence and mortality. Smoking and occupational–environmental exposure are well established to be the major etiological risk factors for lung cancer risk ( 1).The carcinogenic polycyclic aromatic hydrocarbons (PAHs) and the tobacco-specific … WebSep 29, 2024 · CLPTM1L is the homologous protein gene of CLPTM1. CLPTM1 was reported for the first time in a cleft lip and palate family with a translocation breakpoint … fencing banbury https://wilhelmpersonnel.com

Functional Characterization of CLPTM1L as a Lung Cancer …

WebAssociations Between TERT-CLPTM1L Variants and Risk of Cancer and Non-Cancer Diseases. We conducted meta-analyses to assess relationships of 23 variants in TERT … OVCAR4, HeyA8, PeO1, PeO4 Panc1, MiaPaCa2, CaPan2, A549, H226, and H520 human tumor cells were obtained from ATCC. A2780 parental and cisplatin resistant A2780cis cells were obtained from Millipore Sigma (St. Louis, MO). OVCAR5 cell line was purchased from NCI-DCTD repository and authenticated … See more A full FDA panel of normal human tissues on tissue microarray (TMA) (H1.0 × 144) was obtained from Proteogenex (Inglewood, CA). A … See more Cells were plated on 24-well tissue culture plates at equal density (~80) confluence and allowed to attach overnight before treatment as indicated in at least triplicate. Culture media contained yoyo-1 fluorescent DNA … See more Protein expression was accessed by western blotting as discussed earlier35. Briefly cells were lysed with 100 μL of 1× NP40 lysis buffer containing proteinase inhibitors, sheared … See more Cells were plated at equal density on 24-well tissue culture plates and treated as indicated. Cells were treated with monoclonal anti-CLPTM1L for 24 h followed by 72 h of … See more WebFeb 1, 2007 · Figure 1. Transductional targeting for increasing gene transfer into prostate cancer cells. A-D, cell lines were infected with replicationdeficient luciferase expressing Ad5luc1, and isogenic capsidmodified viruses Ad5/3luc1 and Ad5lucRGD. Ad5luc1 has a wildtype Ad5 capsid, whereas Ad5/ 3luc1 and Ad5lucRGD feature capsids modified with … deglutathionylate

Rs401681 polymorphism in TERT-CLPTM1L was associated with …

Category:The TERT-CLPTM1L lung cancer susceptibility variant associates …

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Clptml1 cancer scholar

Association between CLPTM1L-TERT rs401681 polymorphism and …

WebJun 4, 2012 · Cleft Lip and Palate Transmembrane Protein 1-Like (CLPTM1L), resides in a region of chromosome 5 for which copy number gain has been found to be the most … WebCLPTM1L is believed to be associated with lung cancer. However, there is little information regarding its expression and function. Here using immunohistochemistry, we found that …

Clptml1 cancer scholar

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WebJan 17, 2015 · The rs401681 polymorphism was located in the intron 13 of CLPTM1L and 27 kb from the TERT, which has been widely reported to be associated with an … WebDec 16, 2016 · Several genome-wide association studies (GWAS) have identified TERT-CLPTM1L as plausible causative locus for lung cancer …

WebSep 29, 2024 · This study aimed to explore the function of CLPTM1L in oral squamous cell carcinoma and mechanism of tumorigenesis. The expression of CLPTM1L was detected …

Web10). The variant was also significantly associated with triple-negative (ER-negative, progesterone receptor (PR)-negative and human epidermal growth factor-2 (HER2)-negative) breast cancer (OR = 1.25, P = 1.1 × 10 -9), particularly in younger women (<50 years of age) (OR = 1.48, P = 1.9 × 10 -9).Our results identify a genetic locus associated … WebFeb 28, 2014 · To date, many studies have indicated that CLPTM1L and TERT genes were candidate susceptible genes for many diseases, in which SNPs and CNV were reported …

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WebSep 29, 2024 · Multiple genome-wide association studies (GWAS) have demonstrated that the TERT-CLPTM1L genetic variation at 5p15.33 is correlated with the risk of various malignant tumors, such as lung cancer, cervical cancer, pancreatic cancer, bladder cancer, glioma, prostate cancer, basal cell carcinoma and melanoma, and oral cancer … degloving injury of footWebFeb 6, 2016 · Variants of the cleft lip and palate trans-membrane 1 like (CLPTM1L) gene, located on chromosome 5p15.33, were previously determined to influence lung cancer susceptibility. Here, we performed a case-control study to examine the potential association of CLPTM1L single nucleotide polymorphisms (SNPs) with lung cancer in a Chinese … degloving injury of handsWebJul 14, 2024 · The mechanism of the lumenal translocation of GlcN-PI is unclear. We report that Cleft lip and palate transmembrane protein 1-like protein (CLPTM1L), an ER membrane protein of unknown function, is a lipid scramblase involved in GPI biosynthesis. Purified CLPTM1L scrambles GlcN-PI, PI, and several other phospholipids in vitro. degloving injury of finger icd 10WebDec 26, 2012 · In the hope of defining the pathogenesis of CLPTM1L in lung cancer, we focused on CLPTM1L expression, cellular localization and functional association with lung cancer. We found that CLPTM1L was … deglutition define theory definitionWebMar 29, 2024 · Introduction. The incidence of oral squamous cell carcinoma (OSCC) has increased in the recent years. Despite progress in chemotherapy and radiotherapy, the prognosis of advanced OSCC remains unfavorable [].This is contrary to the improved prognosis of patients with other cancers, such as breast cancer, lymphoma, lung … fencing bansteadWebDec 26, 2012 · CLPTM1L is believed to be associated with lung cancer. However, there is little information regarding its expression and function. Here using immunohistochemistry, we found that CLPTM1L expression … deglycosylated massWebCLPTM1L transferred lung cancer cell line 95-D showed no growth inhibition or cell apoptosis, but it did show inhibited sensitivity to cis-diamminedichloroplatinum(II) (cisplatin, CDDP). Knockdown of CLPTM1L by RNAi did not interfere with cell proliferation but it did increase cell sensitivity to CDDP and activation of caspase-9 and caspase-3/7. fencing banners