Cisplatin an anticancer compound contains
Cisplatin interferes with DNA replication, which kills the fastest proliferating cells, which in theory are cancerous. Following administration, one chloride ion is slowly displaced by water to give the aquo complex cis-[PtCl(NH3)2(H2O)] , in a process termed aquation. Dissociation of the chloride is favored inside the cell because the intracellular chloride concentration is only 3–20% of the approxi… WebNeurotoxicity is an obvious adverse effect in Patients encountering a complete course of chemotherapy. The present work is conducted to evaluate the neuroprotective effect of Ginkgo biloba (Ginkgo) against the neurotoxicity induced by Cisplatin (Cis) in rats. Forty male Wistar albino rats were arranged into four groups: (1) Control group, rats were …
Cisplatin an anticancer compound contains
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WebMay 23, 2013 · Cisplatin, as its name implies, contains a platinum core with two chloride leaving groups and two amine nonleaving groups ( Figure 1 ). After cell entry, aquation of the chloride groups allows the platinum to bind guanine residues and, to a lesser extent, adenine residues to form adducts on DNA. WebSep 1, 2024 · Cisplatin for injection is a cytotoxic drug. Follow applicable special handling and disposable procedures. 1 Reconstitution Reconstitute 50 mg vials with 50 mL of …
WebCisplatin is a major anticancer drug that kills cancer cells by damaging their DNA and inducing apoptosis. Cisplatin is a small and remarkably simple molecule composed of one platinum atom linked to two amides and two chlorides. WebApr 6, 2024 · Complete answer: In cisplatin there is one atom of platinum, three molecules of ammonia and two atoms of Chlorine. Cisplatin is a coordination compound. …
WebJan 28, 2024 · So, the anticancer properties of cisplatin arise from the substitution of the chlorine ligands with nucleophiles, such as DNA strand, hindering the replication of cancer cells. Interestingly, normal cells can manage DNA damage caused by cisplatin with the help of in-built repair mechanisms. 3.3. Mechanisms of Action WebCisplatin (NSC 119875, Cisplatinum, cis-diamminedichloroplatinum II, CDDP, cis DDP, DDP) is an inorganic platinum complex, which is able to inhibit DNA synthesis by …
WebPlatinum compounds form DNA adducts, which ultimately result in activation of p53-dependent and p53-independent apoptosis.24 As monotherapy, cisplatin has anticancer activity comparable with that of other single agents, leading to response rates of approximately 15% and a median survival of 6 to 8 months. 21 In order to increase the …
WebCisplatin or (SP-4-2)-diamminedichloridoplatinum(II) is one of the most potential and widely used drugs for the treatment of various solid cancers such as testicular, ovarian, head … cz ペンダント ネックレスWebDec 1, 2024 · Cisplatin is a chemotherapeutic drug that suppresses tumour's growth. • Cisplatin’s effectiveness is limited as it causes liver toxicity. • Various natural antioxidants protect against cisplatin-induced hepatotoxicity. • Hepatoprotective mechanisms are antioxidant, anti-inflammatory, and anti-apoptosis. cz処理 ブラウン処理WebCis-platinum Compounds Cisplatin, (cis-[PtCl 2(NH 3) 2], also known as cis-DDP) ((1), Figure 2) is perhaps the best known example of a small molecule metal-containing drug. The clinically used platinum complexes are shown in Figure 2. cz ピアス と はWebCisplatin has a square planar platinum center that coordinates four ligands, two chloride and two ammonium. The cis formation of this compound is responsible for the … cz処理 とはWebJul 1, 2024 · Cisplatin exerts anticancer activity via multiple mechanisms but its most acceptable mechanism involves generation of DNA lesions by interacting with purine … cz処理とは 基板WebFeb 22, 2024 · Terpenoids are bioactive compounds with a variety of pharmacological activities, including anticancer activity. This review paper aimed to focus on the anticancer activities of certain terpenoids, including their molecular … cz処理 メックWebJan 1, 2012 · It has since become the most widely used anticancer drug, with an estimated 70% of patients receiving the compound as part of their treatment. 1. Cisplatin . Cisplatin was heralded as a completely novel … cz両袖デスク