WebDec 1, 1999 · Initial experiments showed that CD47 ligation by immobilized anti-CD47 antibodies (B6H12 and 2D3), TSP1 or TSP peptide-mimic 4N1K, induces … WebAug 22, 2024 · CD47 can be found expressed on virtually all immune cells, but the level of expression varies markedly in severity depending on cell types and pathologic conditions ( 2 ). For T cells, CD47 signaling is associated with a wide array of cellular processes, from activation to induction of deaths ( 44 ).
National Center for Biotechnology Information
WebIn its capacity as a thrombospondin-1 (TSP-1) receptor, CD47 has recently been shown to mediate cell... CD47 Ligation Induces a Rapid Caspase‐Independent Apoptosis‐Like Cell Death in Human Monocytes and Dendritic Cells - Johansson - 2004 - Scandinavian Journal of Immunology - Wiley Online Library WebAug 1, 2024 · CD47-ligation induced cell death in T-acute lymphoblastic leukemia. Cell Death Dis (2024) R. Advani et al. ... Preclinical research supports several models of antibody-mediated blockade of CD47-SIRPα resulting in cell death signaling, phagocytosis of cells bearing stress signals, and priming of tumor-specific T cell responses. ... the gang of four china
CD47-ligation induced cell death in T-acute lymphoblastic …
WebDec 14, 2024 · The results show that PKHB1 can induce ICD in leukemic cells as it induces CRT exposure and DAMP release in vitro, and prophylactic vaccinations inhibit tumor establishment in vivo, improving the knowledge of CD47 agonist peptides potential as therapeutic tools to treat leukemia. T‐cell acute lymphoblastic leukemia (T‐ALL) has a … WebMar 10, 2009 · In chronic lymphocytic leukemia, CD47 ligation induces one of these alternative forms of cell death: type III programmed cell death. This poorly understood process is characterized by cytoplasmic hallmarks, such as mitochondrial damage. the gang of oss 2011