WebJan 30, 2009 · Treatment with calf intestinal phosphatase demonstrated that these alterations in Bim migration were due to phosphorylation and subsequent de-phosphorylation of Bim. Bim becomes hyper-phosphorylated during mitotic arrest (Fig. 2A, compare lanes 4 and 5) and undergoes de-phosphorylation as cells become apoptotic … WebJun 24, 2011 · Although cisplatin can induce ERK ( 25, 26) and ERK can phosphorylate Bim to target it for degradation, it is unclear thus far whether Bim degradation via cisplatin-induced ERK-mediated phosphorylation plays a role in cisplatin resistance, which is the focus of this study. In this study, we showed that cisplatin induces ERK activation, and …
ERK signalling: a master regulator of cell behaviour, life …
WebDec 9, 2009 · Bim is a critical regulator for the development and normal responses of various immune systems. Bim deficiency causes abnormal accumulation of lymphoid … WebFeb 16, 2012 · BIM phosphorylation was dependent on MEK1/2 kinase activity, and we identified BIM(EL) serine 69, previously linked to pro-survival responses, as the major … smoczek avent classic
Phospho-Bim (Ser55) Antibody Cell Signaling Technology
WebSep 13, 2024 · PF increased BIM and PUMA proteins and slightly reduced AKT phosphorylation. Importantly, PF further enhanced osi-induced upregulation of BIM and PUMA proteins as well as suppression of AKT and FOXO1/3 phosphorylation while having a minimal effect on ERK phosphorylation (Figure 2 D). WebBim/Bod is a pro-apoptotic protein belonging to the BH3-only group of Bcl-2 family members including Bad, Bid, Bik, Hrk, and Noxa that contain a BH3 domain but lack other conserved BH1 or BH2 domains (1,2). Bim induces apoptosis by binding to and antagonizing anti-apoptotic members of the Bcl-2 family. Interactions have been observed with Bcl-2 ... WebPro-apoptotic Bim phosphorylation results in ubiquitin-mediated degradation of Bim and decreased inhibition of anti-apoptotic Bcl-2 and Bcl-xL proteins. Phosphorylation of Bid in … smoc worcester shelter