Alcohol telomere
WebSep 21, 2024 · Alcohol’s impact on telomere length, a proposed marker of biological age, is unclear. We performed the largest observational study to date and compared findings with Mendelian randomization (MR) estimates. Two-sample MR used data from a recent genome-wide association study (GWAS) of telomere length. Genetic variants were … Participants were drawn from UK Biobank [16], a prospective cohort study which recruited ~500,000 volunteers aged 40–69 years in 2006–10. UK Biobank received ethical approval from the Research Ethics Committee … See more Genetically-predicted alcohol consumption was ascertained using an instrument composed of 93 variants associated with alcohol consumption (log drinks per week) with genome-wide significance (GWS) in the largest published … See more We used two different alcohol trait definitions, to correspond to alcohol quantity and AUD. 1) Alcohol consumption was self-reported at … See more LTL measurements were ascertained on DNA collected at the baseline assessment using a well-validated qPCR assay [19]. Measurements were reported as a ratio of the telomere repeat … See more
Alcohol telomere
Did you know?
WebMar 13, 2014 · It is widely believed that lifestyle features such as smoking, obesity, physical inactivity, and possibly alcohol intake enhance shortening of telomeres. However, strong evidence to support such an interpretation is hard to find. WebJul 26, 2024 · Abstract. Alcohol's impact on telomere length, a proposed marker of biological aging, is unclear. We performed the largest observational study to date (in n …
WebMar 24, 2024 · An association of alcohol consumption with shortening of telomeres has been shown in some studies with certain populations, including individuals with alcohol abuse, alcohol dependence and some ... WebJul 26, 2024 · Alcohol’s impact on telomere length, a proposed marker of biological aging, is unclear. Determining the connection between the two has been challenging due to the lack of reliable methods. Now, scientists from Oxford Population Health, in a new study, offered evidence that alcohol directly accelerates aging by damaging DNA in telomeres.
WebDec 10, 2024 · Telomeres maintain the integrity of chromosomes, the stability of the genome, and prevent end-to-end chromosomal fusions 6. When telomerase activity is lacking, DNA polymerase is unable to fully... WebApr 10, 2024 · Canonical telomeres (telomerase-synthetised) are readily forming G-quadruplexes (G4) on the G-rich strand. However, there are examples of non-canonical telomeres among eukaryotes where telomeric tandem repeats are invaded by specific retrotransposons. Drosophila melanogaster represents an extreme example with …
WebAug 9, 2012 · There are scarce data of alcohol consumption and telomere length, an indicator of biological age. In 1974, detailed alcohol consumption was available for a socioeconomically homogenous cohort of middle-aged men (The Helsinki Businessmen Study). Their alcohol use, divided into 5 groups (zero, 1–98, 99–196, 197–490, >490 …
WebFeb 23, 2011 · In conclusion, our results show that abuse in alcohol drinking is associated with shortened telomeres which suggests a premature aging at the cellular level as … hudson coat rackWebAug 9, 2012 · The data on alcohol consumption probably reflect the peak of alcohol consumption during healthy lifetime on telomeres in old age. Telomere measurements … hudson cobras footballWebJul 27, 2024 · In the MR analysis, the team found a clear link between high alcohol intake and shorter telomeres – drinking 32 units of alcohol (about 11 glasses of wine) per … hudson cod wikiWebMar 26, 2024 · Their analysis suggests that telomere length is associated with alcohol consumption. Given that shorter telomeres, before they reach the critical length, can … holder swap coinWebJul 27, 2024 · Today, researchers from Oxford Population Health have published results from a new genetic-based analysis which suggest that alcohol directly accelerates aging by damaging DNA in telomeres. The findings are published today in Molecular Psychiatry. Telomeres are repetitive DNA sequences that cap the end of chromosomes, protecting … hudson coatsWebJul 27, 2024 · The MR analysis also found a significant association between genetically-predicted alcohol-use disorder and telomere length, equivalent to around 3 years of … hudson cocktail company basil crushWebApr 9, 2024 · HIGHLIGHTS. who: A. Topiwala from the (UNIVERSITY) have published the research: Alcohol consumption and telomere length: Mendelian randomization clarifies alcoholu2812s effects, in the Journal: (JOURNAL) of 26/07/2024 what: Despite this, the analysis had 85% statistical power to detect a 0.08 standard deviation change in … hudson cobras high school